Psilocybin or 'magic mushrooms' found to temporarily 'dissolve' parts of brain network

By Jurassic JennJul 20, 2024 14:52 PMScience
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Psilocybin. Source: https://newsroom.uw.edu/

Recent studies reveal profound changes in the brain brought about by psilocybin, the active ingredient in magic mushrooms. Brain scans indicate that psilocybin temporarily disrupts normal neural communication, particularly within the default mode network (DMN)—a brain region involved in creating our sense of self. This disruption results in a significant alteration of brain network synchronicity, contributing to the drug's trippy effects. This is prepared by SSP.

Key Findings from Brain Scans

Researchers conducted comprehensive brain scans to delve deeper into psilocybin's effects. For instance, a study involving seven participants used functional MRI (fMRI) scans to capture neural activity before, during, and after psilocybin intake. These scans showed that psilocybin can massively affect the DMN, making it highly disordered. This chaos correlates with the so-called ego dissolution and altered perception of time and space associated with psychedelic experiences.

MRI scan. Source: https://www.medicalnewstoday.com/

Long-lasting Neural Changes

Most psilocybin-induced neural changes are short-lived, vanishing days after intake. However, decreased coordination between the DMN and parts of the hippocampus—areas associated with memory and emotion—can persist for weeks. This lasting effect has intrigued researchers as it might underpin psilocybin’s therapeutic potential in treating depression and other mental health conditions.

Therapeutic Implications

These discoveries paint a more complex picture of how psilocybin interacts with the brain, suggesting that the drug doesn't merely increase or decrease brain activity but rather reconfigures neural connections. This plasticity could facilitate new therapeutic pathways by enabling longer-term cognitive and emotional benefits. Importantly, the therapeutic context, including controlled environments and careful monitoring, plays a crucial role in safely harnessing these benefits.

Conclusion

Psilocybin's intervention in brain connectivity generates significant, albeit temporary, changes, reshaping our understanding of its potential therapeutic applications. The intricacies of how this psychedelic impacts neural dynamics, particularly within the DMN, underline its promise and complexity as a treatment option for mental health disorders. Future research will be pivotal in fully appreciating and optimizing these effects to develop effective therapies.

Earlier, SSP reported that comet predicted to light up Earth's skies this fall may be falling apart.

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